Antonine Plague
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The Antonine Plague of AD 165 to 180, also known as the Plague of Galen, was a prolonged and destructive epidemic, which impacted the Roman Empire. It was possibly contracted and spread by soldiers who were returning from campaign in the Near... Wikipedia
Start date: 165 AD
End date: 190 AD
Date: 165-180
Deaths: 5–10 million (estimated)
Disease: probably smallpox
Fatality rate: 25 percent
First reported: Seleucia