Isabel de Bobadilla, or Inés de Bobadilla was the first female governor of Cuba from 1539–1543. Wikipedia
Born: 1505, Spain
Died: 1546 (age 41 years), Spanish Empire
Spouse: Hernando de Soto (m. 1537–1542)
Parents: Pedro Arias Dávila
Great-grandparent: Diego Arias Dávila
Grandparent: Pedro Arias Dávila y González
Previous office: Governor of Cuba (1539–1544)