Plague of Justinian
Pandemic
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The plague of Justinian or Justinianic plague was an epidemic that afflicted the entire Mediterranean Basin, Europe, and the Near East, severely affecting the Sasanian Empire and the Byzantine Empire, especially Constantinople. Wikipedia
Start date: 541 AD
Date: 541–549
Deaths: 15 million – 100 million (estimated)
Disease: Bubonic plague
Location: Mediterranean basin, Europe, Near East