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Mutt and Jeff

Comic strip
Mutt and Jeff was a long-running and widely popular American newspaper comic strip created by cartoonist Bud Fisher in 1907 about "two mismatched tinhorns". It is commonly regarded as the first daily comic strip. Wikipedia
End date: June 26, 1983
Author(s): Bud Fisher (1907–1932); Al Smith (1932–1980); George Breisacher (1980–1983)
Creator: Bud Fisher
Genre(s): Humor
Launch date: November 15, 1907