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Arkham Asylum

The Elizabeth Arkham Asylum for the Criminally Insane, commonly referred to as Arkham Asylum, is a fictional psychiatric hospital/prison, appearing in American comic books published by DC Comics, commonly in stories featuring the superhero Batman.... Wikipedia
Characters: Most of Batman's adversaries; Hugo Strange; Jeremiah Arkham; Amadeus Arkham; Aaron Cash
Created by: Dennis O'Neil (writer); Irv Novick (artist)
First appearance: Batman #258 (October 1974)